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pandora bracelets We calculated body mass index by using the first set of height and weight data available for each patient. We defined smoking history as past or current tobacco use and chronic kidney disease as the presence of a diagnosis code associated with chronic kidney disease (except stage 1 or 2 chronic kidney disease) or an estimated glomerular filtration rate less than 60 mL/min/1.73 m2 (supplementary table C).18 We calculated a medication possession ratio (as a proxy for compliance) for each patient as a weighted average of the number of days’ supply actually prescribed for each medication, divided by the total period of time over which that medication was prescribed.19 We calculated the Charlson comorbidity index from the Read code list by using a previously described and validated method, while excluding conditions individually included in the multivariable analysis.20We estimated socioeconomic status by using the Townsend socioeconomic deprivation score, which is calculated using economic and demographic data based on the patient’s postal code.21 Patients who had multiple addresses during the follow up period had their Townsend deprivation score calculated as a weighted average based on time spent living at each address.Statistical analysisWe produced summary statistics by using frequencies and proportions for categorical variables and means, standard deviations, medians, and ranges for continuous variables. We used a Cox proportional hazards regression model to compare event free survival for patients with various treatment strategies as defined by systolic intensification threshold, time to intensification, and time to follow up.22 The analysis was adjusted for the entry age category (20 23 24 as well as for sex, smoking status, Townsend score, previous history of diabetes/cardiovascular disease/chronic kidney disease, Charlson comorbidity index, body mass index, medication possession ratio, and the mean difference by which systolic blood pressure exceeded the minimum intensification threshold at the beginning of each hypertensive period.25 We used multiple imputation in the sensitivity analysis that included patients with missing demographic or body mass index information.We anticipated that treatment target, time to intensification, and time to follow up may have a non linear relation to risk of an event, with an optimal range of values and increased hazards outside this range. pandora bracelets

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